2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-135194R
    Risperidone E-oxime (Standard)
    Risperidone E-oxime (Standard) is the analytical standard of Risperidone E-oxime. This product is intended for research and analytical applications. Risperidone E-oxime is an impurity of Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively .
    Risperidone E-oxime (Standard)
  • HY-165423
    DM-4111
    DM-4111, one of the major monohydroxyl metabolites of Tolvaptan (HY-17000), is a potent vasopressin V2 receptor inhibitor. DM-4111 inhibits water reabsorption in the renal tubules, thereby promoting the excretion of electrolyte-free water. DM-4111 is promising for research of cardiovascular diseases.
    DM-4111
  • HY-137532S
    7-Hydroxy Quetiapine-d8
    7-Hydroxy Quetiapine-d8 is the deuterium labeled 7-Hydroxyquetiapine. 7-Hydroxyquetiapine (ICI 214227) is the major active metabolite of antipsychotic medicine Quetiapine.
    7-Hydroxy Quetiapine-d<sub>8</sub>
  • HY-164920
    WR 199507 trihydrobromide
    WR 199507 trihydrobromide, a putative Primaquine (HY-12651A) metabolite, causes methemoglobin formation in canine hemolysates.
    WR 199507 trihydrobromide
  • HY-169464
    Cannabinol-7-oic acid
    Cannabinol-7-oic acid is a metabolite of cannabinol that can be found in faeces.
    Cannabinol-7-oic acid
  • HY-W353006
    Desmethyl Lacosamide
    Desmethyl Lacosamide is a metabolite of Lacosamide (an antiepileptic compound).
    Desmethyl Lacosamide
  • HY-W035375
    Mephedrone metabolite (hydrochloride) ((±)-ephedrine stereochemistry)
    		Control
    Mephedrone metabolite hydrochloride ((±)-ephedrine stereochemistry), a cathinone metabolite, is a metabolite of Mephedrone.
    Mephedrone metabolite (hydrochloride) ((±)-ephedrine stereochemistry)
  • HY-133925S2
    6-O-Desmethyl donepezil-d7
    6-O-Desmethyl donepezil-d7 is deuterated labeled 6-O-Desmethyl donepezil.
    6-O-Desmethyl donepezil-d<sub>7</sub>
  • HY-16445A
    CNDAC
    CNDAC is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC induces DNA damage and apoptosis.
    CNDAC
  • HY-W012481
    Nirvanol
    Nirvanol (Ethylphenylhydantoin) is a metabolite of Mephenytoin (HY-B1184) that exerts anticonvulsant effects in the maximal electroshock (M.E.S.) seizure model in mice. Nirvanol shows potential for research in epilepsy-related neurological disorders.
    Nirvanol
  • HY-W588187
    Coprostanone
    Coprostanone (5β-cholestan-3-one) is an oxysterol and active metabolite of Cholesterol (HY-N0322). Coprostanone induces apoptosis in primary dog gallbladder epithelial cells. Coprostanone is promising for research of colon cancers or adenomatous polyps.
    Coprostanone
  • HY-137772
    Captopril EP Impurity E
    Captopril EP Impurity E is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM).
    Captopril EP Impurity E
  • HY-139199R
    4-Hydroxyphenylbutazone (Standard)
    4-Hydroxyphenylbutazone (Standard) is the analytical standard of 4-Hydroxyphenylbutazone. This product is intended for research and analytical applications. 4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory agent (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS).
    4-Hydroxyphenylbutazone (Standard)
  • HY-Y1314R
    Dimethyl sulfone (Standard)
    Dimethyl sulfone (Standard) is the analytical standard of Dimethyl sulfone. This product is intended for research and analytical applications. Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective.
    Dimethyl sulfone (Standard)
  • HY-116687S
    7-Aminoflunitrazepam-d7
    7-Aminoflunitrazepam-d7 is deuterium labeled 7-Aminoflunitrazepam.
    7-Aminoflunitrazepam-d<sub>7</sub>
  • HY-W704657
    Monobutyl phosphate-d9
    Monobutyl phosphate-d9 is the deuterium labeled Monobutyl phosphate (HY-N7143). Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects.
    Monobutyl phosphate-d<sub>9</sub>
  • HY-N13366
    3-Methylcrotonyl CoA
    3-Methylcrotonyl CoA is a key metabolic intermediate in the leucine degradation pathway, converted to 3-Methylglutaconyl CoA by 3-Methylcrotonyl CoA Carboxylase. Normally, 3-Methylglutaconyl CoA is catalyzed by 3-Methylglutaconyl-CoA Hydratase into 3-Hydroxy-3-methylglutaryl-CoA (HMG CoA). However, mutations in 3-Methylglutaconyl-CoA Hydratase lead to the accumulation of 3-Methylglutaconyl CoA, causing metabolic disorders associated with 3MGA-uria. 3-Methylcrotonyl CoA is useful for research into metabolic diseases related to the leucine degradation pathway.
    3-Methylcrotonyl CoA
  • HY-113083R
    Acetaminophen glucuronide (Standard)
    Acetaminophen glucuronide (Standard) is the analytical standard of Acetaminophen glucuronide. This product is intended for research and analytical applications. Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005). Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
    Acetaminophen glucuronide (Standard)
  • HY-B1180R
    Vinburnine (Standard)
    Vinburnine (Standard) is the analytical standard of Vinburnine. This product is intended for research and analytical applications. 0
    Vinburnine (Standard)
  • HY-145991R
    Ribavirin carboxylic acid (Standard)
    Ribavirin carboxylic acid (Standard) is the analytical standard of Ribavirin carboxylic acid. This product is intended for research and analytical applications. Ribavirin carboxylic acid (TR-COOH) is a metabolite of Ribavirin (HY-B0434), Ribavirin has strong antiviral activity.
    Ribavirin carboxylic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity